According to the WHO recommendations, the indications for the introduction of an HAV universal mass vaccination (UMV) strategy into national immunization schedules are as follows: (i) an increasing trend over time of acute hepatitis A disease, including severe disease, among older children, adolescents, or adults; (ii) changes in endemicity from high to intermediate; and (iii) considerations of cost-effectiveness ( 9 ).
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Modeling hepatitis A epidemiological profiles and estimating the pediatric vaccination threshold in the Russian Federation.
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