The adjunctive use of antimicrobial photodynamic therapy, light-emitting-diode photobiomodulation and ozone therapy in regenerative treatment of stage III/IV grade C periodontitis: a randomized controlled clinical trial.

For all the groups, an increasing trend was noted for the osterix expression at T3, which demonstrated the greatest expression levels according to all study follow-ups, and then the levels decreased back to baseline levels at T6.

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PI showed a decreasing trend at T3 compared to baseline in all the groups, but increased at T6 compared to T0 and T3, except for photobiomodulation group.

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