Long-Term Proton Pump Inhibitor-Acid Suppressive Treatment Can Cause Vitamin B₁₂ Deficiency in Zollinger-Ellison Syndrome (ZES) Patients.

As seen in Figure 3 A,B, there was a highly significant negative correlation (r = −0.304 and r = −0.335) ( p < 0.0001) between the serum VB 12 level and the serum MMA level ( Figure 3 A) or between the serum VB 12 level and the plasma tHCY level ( Figure 3 B) in a given patient, and the serum MMA level directly (r = 0.437) and significantly ( p < 0.0001) correlated with the plasma tHCY level in a given patient ( Figure 3 C). 2.3.

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