Low-dose aspirin for the prevention of atherosclerotic cardiovascular disease.

8 , 34 In the Second International Study of Infarct Survival, once-daily dosing with low-dose aspirin (162.5 mg) started within 24 h of the onset of symptoms of a suspected MI produced highly significant reductions in 5 week vascular mortality (the primary endpoint) by 23%, non-fatal reinfarction by 49%, and non-fatal stroke by 46% in over 17 000 patients. 35 Three smaller but longer-term (12 weeks to 2 years) placebo-controlled RCTs in ∼2600 patients with unstable coronary artery disease consisten

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