highly significantp < 0.001
In addition, reduced (≤2.0) coronary flow reserve (CFR) determined using 2D echocardiography in patients with diabetes and negative dipyridamole stress echocardiography carries highly significant and convincing worse outcome in comparison with preserved CFR (>2.0) over a follow-up of 3 years (58% vs. 16%, p < 0.001) [ 27 ].