Sex-biasing influence of autism-associated <i>Ube3a</i> gene overdosage at connectomic, behavioral, and transcriptomic levels.

This evidence of highly significant PPIs (actual edges = 1015, expected edges = 405, P < 1.0 × 10 −16 ) and highly ASD-relevant GO BP enrichment showcases a clear example of how the PFC sex*genotype DE genes are embedded within a complex systems-level biological pathology that integrates abnormalities along these key processes and pathways.

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In contrast, Ube3a2X males displayed a nonsignificant trend for increased functional connectivity in both prefrontal and hypothalamic areas ( P = 0.10; Fig. 1B ).

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