Multiscale modeling uncovers 7q11.23 copy number variation-dependent changes in ribosomal biogenesis and neuronal maturation and excitability.

The 7q11.23-sensitive genes showed highly significant enrichments for several biological processes, with ribosomal genes and translation initiation factors being downregulated when 7q11.23 copy number dosage was increased ( Figure 3B in red, and Figure 3C ), whereas ion channels and synaptic transmission genes were upregulated ( Figure 3B in green, and Figure 3D ), all changes in alignment with aforementioned symmetrically altered kinetics of differentiation ( 26 , 27 ).

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