We then calculated the percentages of major tumor-infiltrating immune lineage in each individual sample, and found that compared with control group, the proportion of CD4 + T cells, CD8 + T cells and NK cells in tumors from AB680-treated group displayed an increasing trend, while the proportion of macrophages and neutrophils showed a decreasing trend (Fig. 6 F).
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Targeting CD73 limits tumor progression and enhances anti-tumor activity of anti-PD-1 therapy in intrahepatic cholangiocarcinoma.
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