We found the following: (a) The effect of Virus was highly significant (P < 0.001, Greenhouse–Geisser test), with JCV and BLV having lower average PBA scores (Fig. 2 ); (b) The effect of HLA Class was also highly significant (P < 0.001, F-test), with HLA-I having 2.5 × higher scores than HLA-II (Fig. 3 A); and (c) the Virus x Class interaction term was also highly significant (P < 0.001, Greenhouse–Geisser test) (Fig. 3 B).
4 , right panel); (b) for HLA-I, there was a marginally significant effect of Gene (P = 0.024, F-test), with higher PBA values for gene C (Fig. 5 A), whereas the Virus × Gene effect was not statistically significant (P = 0.166, Greenhouse–Geisser test) (Fig. 5 B); (c) For HLA-II, there was a significant effect of Gene (P = 0.011, F-test), with higher PBA values for gene DQB1 (Fig. 6 A), and the Virus × Gene effect was highly significant (P < 0.001, Greenhouse–Geisser test) (Fig. 6 B).