A chromatography-free one-pot, two-step synthesis of 1,2,4-thiadiazoles from primary amides <i>via</i> thiolation and oxidative dimerization under solvent-free conditions: a greener approach.

1 Among these, 1,2,4-thiadiazole is a highly significant heterocyclic compound in the field of medicinal chemistry and agrochemical research. 2 Its unique molecular structure, consisting of a five-membered ring containing sulfur and nitrogen atoms, offers a robust foundation for designing compounds with specific biological activities. 3 For example, the

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