43 Transcriptomic analysis shows that genes in CrF exhibiting an increasing trend are associated with immune cell responses, specifically B‐cell and T‐cell activation.
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Conversely, genes showing a decreasing trend in CrF are involved in cell trafficking and migration, suggesting a heightened state for inflammatory responses. 44 Single‐cell sequencing technology analysis discovered a novel subpopulation of fibroblasts known as FC3 that predominantly accumulate in CrF.