Insights into the production and evolution of lantibiotics from a computational analysis of peptides associated with the lanthipeptide cyclase domain.

Type IIa D-CCC synthetases have a more highly reactive cyclase, which not only modifies lanthipeptides that chromosomally cluster with the synthetase genes but also modifies lanthipeptides encoded by genes scattered over the genomes of two major ecologically highly significant genera of photosynthetic bacteria, Chlorococcus and Synechococcus [ 51 , 52 ].

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