Intravenous esketamine as an adjuvant for sedation/analgesia outside the operating room: a systematic review and meta-analysis.

Subgroup analysis of esketamine regimens showed a significant reduction in the risk of oxygen desaturation (RR = 0.51, 95%CI = [0.35, 0.74], p = 0.0003); hypotension (RR = 0.38, 95%CI = [0.31, 0.46], p < 0.00001); and bradycardia (RR = 0.24, 95%CI = [0.12, 0.47], p < 0.0001) in the esketamine-propofol combination, and a marginally significant reduction ( oxygen desaturation : RR = 0.23, 95%CI = [0.05, 1.06], p = 0.06, and test for subgroup differences p = 0.32; hypotension : RR = 0.26, 95%CI = [0.07, 1.00], p = 0.05, and test for subgroup differences p = 0.59; bradycardia : RR = 0.14, 95%CI = [0.02, 1.12], p = 0.06, and test for subgroup differences p = 0.64) in the esketamine-non-propofol combination in adults.

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