In a circuit necessary for cognition and emotional affect, Alzheimer's-like pathology associates with neuroinflammation, cognitive and motivational deficits in the young adult TgF344-AD rat.

However, in this subset of rats, there was a weak trend in the main effect of genotype irrespective of reward ratio driven by a relatively small numerical difference of 14.9 rewards (F (1,10) = 3.750, p = 0.082, η 2 = 0.273, 1-β = 0.417). 3.2.

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