Biomolecular alterations temporally anticipate microarchitectural modifications of collagen in oral tongue squamous cell carcinoma.

Finally, the RANDOM ratio was analyzed to evaluate the structural organization of the protein component: the lowest values were found in the normal stroma (ExtraT), with an increasing trend going from PeriT S-I to PeriT S-IV and a major extent in the tumor mass (IntraT) ( Figure 7 E).

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