Design, synthesis and characterization of tetra substituted 2,3-dihydrothiazole derivatives as DNA and BSA targeting agents: advantages of the visible-light-induced multicomponent approach.

An absorption maxima for native DNA at 260 nm owing to π → π * transitions is highly significant in discovering ligand-DNA interactions since any change in the microenvironment of the DNA in the presence of a ligand affects this maximum. 15 In literature, it is documented that a bathochromic or hypochromic shift has been observed if a ligand intercalates with DNA helix whereas, in the case of grove binding mode hyperchromic or hypsochromic shift in the absorption maxima has been found.

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