The Remaining Conundrum of the Role of the Na<sup>+</sup>/H<sup>+</sup> Exchanger Isoform 1 (NHE1) in Cardiac Physiology and Pathology: Can It Be Rectified?

Rev Cardiovasc Med · 2022 · PMC11266974 · PMID 39076631

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highly significantno p-value reported

The results from the EXPEDITION trial were promising vis a vis the cardioprotective effects of cariporide in that the incidence of death or MI was reduced from 20.3% in the placebo group to 16.6% in patients treated with cariporide as was the incidence of MI alone (18.9% in the placebo group vs 14.4% in cariporide-treated patients), both highly significant reductions.

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