Genome-wide analyses reveal a potential role for the MAPT, MOBP, and APOE loci in sporadic frontotemporal dementia.

Some of the significant ALS markers as shown in van Rheenen et al., 2021 and Nicolas et al., 2018 28 , 35 reached p = 1.07 × 10 −3 and p = 1.6 × 10 −4 for the UNC13A (MIM: 609894 ) and MOBP loci markers (rs12973192 [proxy] and rs631312, respectively) with similar effects sizes (OR = 1.1), while the C9orf72 marker (rs3849943, highly significant in ALS) showed negligible association in our dataset (probably because of the current study design, i.e., individuals with C9orf72 expansion were excluded from the study).

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