What we do know from the work of Bou-Abboud and Nattel [ 37 ] is that canine Purkinje fibers show small but statistically highly significant increases in their APD 50 (+12.0%) and APD 95 (+5.4%) and in their ( dV m /dt) max (+4.7%) when [ Na + ] e is increased from 141 to 161 mmol/L (14% hypernatremia).
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Effects of Acute Hypernatremia on the Electrophysiology of Single Human Ventricular Cardiomyocytes: An <i>In Silico</i> Study.
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