Differential effects of purified low molecular weight Poly(I:C) in the maternal immune activation model depend on the laboratory environment.

Cytokine analysis revealed highly significant treatment effects for all parameters tested (IL-6, TNF-α, IFN-γ, IL-1β, IL-10) for both dosages of Poly (I:C)(10 mg: IL-6) (F (1,33) = 88.359, p < 0.001), TNF-α (F (1,33) = 86.434, p < 0.001), IFN-γ (F (1,33) = 91.698, p < 0.001), IL-1β (F (1,33) = 57.683, p < 0.001), IL-10 (F (1,33) = 54.602, p < 0.001); 20 mg: IL-6 (F (1,36) = 63.535, p < 0.001), TNF-α (F (1,36) = 51.799, p < 0.001), IFN-γ (F (1,36) = 35.905, p < 0.001), IL-1β (F (1,36) = 33,197, p < 0.001), IL-10 (F (1,36) = 93.540, p < 0.001).

also in 132,142 other papers