Kupffer cells determine intrahepatic traffic of PEGylated liposomal doxorubicin.

Considered ns P > 0.05 as no significant, * P < 0.05 as significant, and ** P < 0.01 even *** P < 0.001 as highly significant.

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For non-PEGylated Lip/Dox, Dox distribution in KC was hysteretic to the PEGylated one, and displayed an increasing trend from 1 to 12 h, indicating differences in KC capture of two different liposomes, largely due to the existence of PEG molecules.

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