Streptococcus suis Serotype 2 Type IV Secretion Effector SspA-1 Induces Proinflammatory Cytokine Production via TLR2 Endosomal and Type I Interferon Signaling.

suis 2 in IFNAR −/− mice in vivo or dendritic cells isolated from IFNAR −/− mice in vitro, the production of IL-6, TNF-α, and certain other inflammatory mediators decreased significantly or at least showed a decreasing trend compared with that in the wild-type counterpart mice and cells [ 25 ].

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