CD74-AKT Axis Is a Potential Therapeutic Target in Triple-Negative Breast Cancer.

Although we previously determined that CD74 exclusively associates with activation-resistant FAS through analysis of primary cell apoptosis in the patients with non-Hodgkin’s lymphoma [ 22 ], these new findings were observed in TNBC cells and are highly significant to target CD74/FAS and CD74/AKT axes with novel approaches to inhibit aggressive breast cancer cells and improve the outcome of patients.

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