The Danish Ibbis Trials for Sickness Absentees with Common Mental Disorders: A Phase 4 Prospective Study Comparing Randomized Trial and Real-World Data.

Adding further complexity, the value of RCT results depends on their generalizability to real-world settings [ 9 ], and if external validity is low due to even lower fidelity when the rigorousness of the RCT setting is changed to a real-world setting, the gap between intervention effect in these domains may be significant [ 10 ].

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