Gastrodin Improves the Activity of the Ubiquitin-Proteasome System and the Autophagy-Lysosome Pathway to Degrade Mutant Huntingtin.

Q74 PC12 cells were incubated with 25 μM GAS for 24 to 48 h, the total intracellular mHtt protein levels were significantly decreased at 24 and 36 h ( p < 0.01), and there was a decreasing trend at 48 h, though with no statistical difference ( Figure 3 a–c).

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