Smad7 palmitoylation by the S-acyltransferase zDHHC17 enhances its inhibitory effect on TGF-β/Smad signaling.

Note that although the degree of silencing was around 45 to 50%, the biological impact was highly significant, and the independent shRNAs exhibited effects corresponding to the degree of zDHHC17 silencing ( Fig. 7 A ).

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