NADPH oxidase 2 activity disrupts Calmodulin/CaMKIIα complex via redox modifications of CaMKIIα-contained Cys30 and Cys289: Implications in Parkinson's disease.

While it's commonly believed that the detrimental redox changes observed in PD stem from mitochondria, emerging evidence suggests that oxygen-related oxidant species production is influenced by a functional interplay between mitochondria and NOX2 [ 21 ], which may be significant in neurodegenerative processes like PD [ 22 ].

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