Protection of K18-hACE2 Mice against SARS-CoV-2 Challenge by a Capsid Virus-like Particle-Based Vaccine.

However, in the RBD-cVLP-vaccinated animals, at day 4 post challenge, a trend towards lower combined lung pathology scores was observed, and at day 6, this difference with the mock-vaccinated controls was statistically highly significant ( p < 0.001; Figure 3 e).

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