Enzyme/ROS dual-sensitive nanoplatform with on-demand Celastrol release capacity for enhanced ulcerative colitis therapy by ROS scavenging, microbiota rebalancing, inflammation alleviating.

Besides, on the condition that C6 concentrations increase from 25 to 200 ng/mL, the intracellular fluorescence intensity also indicates an increasing trend, demonstrating the cellular uptakes of NCM460 cells and Raw264.7 cells were dose-dependent (Fig. 3 C, G).

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