A Kinome-Wide Synthetic Lethal CRISPR/Cas9 Screen Reveals That mTOR Inhibition Prevents Adaptive Resistance to CDK4/CDK6 Blockade in HNSCC.

Cancer Res Commun · 2024 · PMC11284272 · PMID 38954773

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highly significantno p-value reported

Of interest, we also found a highly significant enrichment of cell-cycle pathways ( Fig. 1E ).

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