Identification of 6-Anilino Imidazo[4,5-<i>c</i>]pyridin-2-ones as Selective DNA-Dependent Protein Kinase Inhibitors and Their Application as Radiosensitizers.

1.5 logs of cell kill in HCT116/54C tumors ( Figure 9 A). Both compounds were effective radiosensitizers with 3 somewhat more effective than 78 at equimolar doses. Tumor radiosensitization was confirmed in a second tumor xenograft model (HNSCC line UT-SCC-74B) with highly significant activity of both 3 (75 mg/kg) and 78 (150 mg/kg) ( Figure 9 B).

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