Decoding frontotemporal and cell-type-specific vulnerabilities to neuropsychiatric disorders and psychoactive drugs.

While we found no obvious and consistent correlations between GWAS gene significance and FCs (electronic supplementary material, figure S4 a–g ), we identified GRIN2A and KCNB1 with highly significant GWAS associations ( p < 10 −8 ) in all seven diseases, and more strongly upregulated TL (FDR < 0.05, log 2 FC (TL/FL) > 1) in either both INH/EX ( GRIN2A ) or in INH ( KCNB1 ) ( figure 1 f,h ).

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