Prospective randomized controlled trial on the safety and neuroprotective efficacy of remote administration of hypothermia over spleen during acute ischemic stroke with mechanical thrombectomy: rationale, design, and protocol.

Endovascular hypothermia based on revascularization with an invasive nature has shown a favorable trend in neuroprotection, while the high cost and demanding invasive operational procedure restrict its clinical application ( 37 ). 3.3 Improved neurological function by reducing splenic immune reaction with hypothermia Animal experiments found that systemic mild hypothermia can reduce the splenic immune response ( 31 ).

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