CTHRC1<sup>+</sup> fibroblasts and SPP1<sup>+</sup> macrophages synergistically contribute to pro-tumorigenic tumor microenvironment in pancreatic ductal adenocarcinoma.

Sci Rep · 2024 · PMC11286765 · PMID 39075108

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extremely significantno p-value reported

Further analysis revealed that EMT was an extremely significant mechanism regulated by CTHRC1 + GREM1 + myCAF (Fig. 3 e, f, Supplementary Fig. 2F ), indicating these fibroblasts support cancerous cell differentiation and proliferation leading to rapid tumor growth and potential metastasis.

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CTHRC1&lt;sup&gt;+&lt;/sup&gt; fibroblasts and SPP1&lt;sup&gt;+&lt;/sup&gt; macrophages synergistically contribute to pro-tumorigenic tumor microenvironment in pancreatic ductal adenocarcinoma.

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CTHRC1<sup>+</sup> fibroblasts and SPP1<sup>+</sup> macrophages synergistically contribute to pro-tumorigenic tumor microenvironment in pancreatic ductal adenocarcinoma.