Baseline C-reactive Protein as a Risk Factor for Cryptococcal Meningitis and Death in HIV-associated Cryptococcal Antigenemia With CrAg Titer as an Effect Modifier.

We determined that increasing CRP was significantly associated with increased risk of clinical events in the low CrAg titer group <1:160 (odds ratio = 1.54; 95% CI, 1.16–2.04), whereas the same effect was not found in the high CrAg titer group ≥1:160 (odds ratio = 0.78; 95% CI, .53–1.15), which instead saw a nonsignificant trend toward decreased events, when the model included an interaction term ( P = .005).

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