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Estimating the Global and Regional Burden of Streptococcus pneumoniae Meningitis in Children: Protocol for a Systematic Review and Meta-Analysis.

JMIR Res Protoc · 2024 · PMC11289570 · PMID 39012685

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a decreasing trendno p-value reported
Although the introduction of the vaccine has contributed to a decreasing trend in the burden of pneumococcal meningitis, the reported figures show a marginal reduction within the 15-year period [ 3 , 4 ].

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.