Assessing blood-brain barrier dysfunction and its association with Alzheimer's pathology, cognitive impairment and neuroinflammation.

Neuroinflammation A correlation matrix (Supplementary materials Figure S1 ) between sPDGFRβ and the panel of neuroinflammatory markers revealed one highly significant correlation between sPDGFRβ and YKL-40 ( r = .54, p < .001; Fig. 6 ), which remained significant after Bonferroni-correction for multiple testing and remained significant at the standard significance-threshold in a hierarchical linear regression model controlling for age, sex, and APOE4-status ( b = 0.801, β = 0.461, p = .020).

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