MS-20 enhances the gut microbiota-associated antitumor effects of anti-PD1 antibody.

An increasing trend for CD8 + signals after the administration of anti-PD1 alone or in combination with MS-20 was also observed using immunofluorescence staining (Figure S1i).

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Preliminary fecal metagenomics revealed a positive trend for diversity and toward the enrichment of R. bromii , consistent with the results obtained from M. dubia- treated mice. 54 Briefly, these findings support the idea that the enhanced antitumor function of the anti-PD1 antibody may be mediated through the modulation of the gut microbiota by MS-20.

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