CED-5/CED-12 (DOCK/ELMO) can promote and inhibit F-actin formation via distinct motifs that may target different GTPases.

The genetic results are in general compelling, although the differences are sometimes limited such as the enhancement of wsp-1(gm324) lethality by ced-5/12, or only double lethality such as the effect on let-502(sb118), both of which are slightly indirect and the change in lethality might be significant only at another stage than ventral enclosure; the interactions with Rho-1(RNAi) or Cdc42(RNAi) are also contradictory as to the role of CED-5 vs CED-12 on RhoA.

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