highly significantP < 0.0001
To further evaluate the impact of early intervention vs comorbidity on AsI patients excess mortality, we added early intervention to the comprehensive model for overall survival and observed that early intervention not only remained highly significant ( P < 0.0001), but also reduced the HR attached to AsI patients from 1.60 to 1.15, which became nonsignificant, demonstrating the strong association of low early surgery performance and excess mortality in AsI patients.