Contributions of Germline and Somatic Mosaic Genetics to Thoracic Aortic Aneurysms in Nonsyndromic Individuals.

The genetic contributions of LOF variants in our cohort with TAA remained highly significant when compared with the rates extracted from gnomAD (OR, 3.78 [95% CI, 2.35–6.06], P =3.6×10 −8 ), with no enrichment detected in individuals without TAA versus gnomAD (OR, 1.44 [95% CI, 0.86–2.40], P =0.16).

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