of borderline significancep = 0.766
VBI occurrence was associated with a subsequent anti-S IgG titer increase of 0.13% per day (-0.01% to 0.27%; p = 0.076), although this association was of borderline significance, compared to stable anti-S IgG titers in participants without VBI (0.03% increase per day during day 181–360 [-0.19% to 0.26%]; p = 0.766).