Human effector CD8⁺ T cells with an activated and exhausted-like phenotype control tumour growth in vivo in a humanized tumour model.

Finally, to explore an association of clonal expansion with functionality, we correlated the abundance of the top 10 bona fide tumour-reactive clonotypes of the CD137 + population with in vitro tumour reactivity and found a highly significant correlation of clone size abundance and tumour-specific IFN-γ production by CD8 + T cells ( Fig. 5 h).

also in 132,142 other papers