Heterozygous knockout of Synaptotagmin13 phenocopies ALS features and TP53 activation in human motor neurons.

The expression levels of Syt13 were then assessed by qPCR and, in support of its putative role in determining neuronal vulnerability, we found that the FF MNs isolated from early-stage mutant mice displayed a strong, close to significance ( p -value = 0.0676) down-regulation of this transcript than WT animals (Supplementary Fig. 1B ).

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