Increased opioid consumption in neoadjuvant immunotherapy plus chemotherapy for patients with non-small-cell lung cancer: A multicenter, prospective cohort study.

The incidence of POD showed a decreasing trend in the nCIT group compared with nCT group within 72 h after surgery, although there is no statistical difference (7.32% vs. 10%; RR, 0.732; 95% CI, 0.175–3.065; p = 0.668). 3.4 Exploratory analysis The most severe pain intensity via NRS within 72 h in the nCIT group is significantly higher than that in nCT group (median difference, 1; 95%CI, 0–2; p = 0.043); the difference was clinically significant (Table 3 ).

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