KRAS and TP53 co-mutation predicts benefit of immune checkpoint blockade in lung adenocarcinoma.

Br J Cancer · 2024 · PMC11300455 · PMID 38866964

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highly significantno p-value reported

A strong and highly significant association between KRAS/TP53 and smoking status was found in both HD-ICI and TCGA-LUAD: Significantly higher proportions of smokers (19 and 13%) had KRASmut/TP53mut tumours compared with non-smokers (8 and 5%), whereas slightly higher proportions of smokers had KRASmut/TP53wt and KRASwt/TP53mut compared with non-smokers.

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