Ex-Vivo <sup>13</sup>C NMR Spectroscopy of Rodent Brain: TNF Restricts Neuronal Utilization of Astrocyte-Derived Metabolites.

Furthermore, the significant metabolite changes (selected by inspection of the PCA loadings [ Figure S4 ]) identified following TNF treatment were reproduced in each of the 13 C substrate-infused groups, with the exception of ATP in the 13 C-lactate infused group, which, while showing a decreasing trend similar to all other groups, did not reach significance ( Figure S5 ).

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