DNA mismatch repair defect and intratumor heterogeneous deficiency differently impact immune responses in diffuse large B-cell lymphoma.

According to a previous Ecotyper study in publicly available DLBCL cohorts by Steen et al., 37 the LE4 ecotype was characterized by a higher abundance of immune reactive T cells and was associated with the ABC subtype and unfavorable OS with borderline significance; CD4 T-cell state S2 and neutrophil state S1 had significant associations with unfavorable prognosis.

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