Astrocyte-derived lactate aggravates brain injury of ischemic stroke in mice by promoting the formation of protein lactylation.

First, we examined the expression of p300 in the ischemic brains using the qPCR and the results showed there was an increasing trend in the expression of p300 in the ischemic brains but with little significance between sham and ischemia groups ( Figure S11 A), suggesting that the increase in the formation of protein Kla may be ascribed to the increase in lactate.

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