The optimal dose of dexmedetomidine as a 0.59% ropivacaine adjuvant for epidural anesthesia in great saphenous varicose vein surgery, based on hemodynamics and anesthesia efficacy: a randomized, controlled, double-blind clinical trial.

Compared to 0.5 μg/kg dexmedetomidine epidural infusion group, 0.25 μg/kg and 0.75 μg/kg dexmedetomidine epidural infusion groups showed a smaller decrease in blood pressure, and there was a considerably significant discrepancy ( p < 0.007) at 5 and 15 min of epidural infusion ( Figures 2A , B ), while 0.75 μg/kg dexmedetomidine had a lower descend than 0.5 μg/kg dexmedetomidine in heart rate at 5 min, 15 min, 30 min, and 1 h after epidural infusion ( p < 0.03) ( Figure 2C ).

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